منابع مشابه
Can Invalid Bioactives Undermine Natural Product-Based Drug Discovery?
High-throughput biology has contributed a wealth of data on chemicals, including natural products (NPs). Recently, attention was drawn to certain, predominantly synthetic, compounds that are responsible for disproportionate percentages of hits but are false actives. Spurious bioassay interference led to their designation as pan-assay interference compounds (PAINS). NPs lack comparable scrutiny,...
متن کاملGuiding principles for natural product drug discovery.
Natural products (NPs) have historically been a fertile source of new drugs for the pharmaceutical industry. However, this once-popular approach has waned considerably over the past two decades as the high-throughput screening of megalibraries comprised mainly of molecules with non-natural (synthetic) motifs has unfolded. Contemporary high-throughput screening libraries contain molecules compli...
متن کاملTropical Protozoan Diseases: Natural Product Drug Discovery and Development
1 Department of Pharmacognosy, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, 1113 Buenos Aires, Argentina 2Unitat de Farmacologia i Farmacognòsia, Facultat de Farmàcia, Universitat de Barcelona, 08028 Barcelona, Spain 3 Universidade do Vale do Itajaı́, Núcleo De Investigações Quı́mico-Farmacêuticas (NIQFAR), CCS, Brazil 4Department of Chemistry, University of Alabama in Huntsv...
متن کاملThe role of natural product chemistry in drug discovery.
Although traditionally natural products have played an important role in drug discovery, in the past few years most Big Pharma companies have either terminated or considerably scaled down their natural product operations. This is despite a significant number of natural product-derived drugs being ranked in the top 35 worldwide selling ethical drugs in 2000, 2001, and 2002. There were 15 new nat...
متن کاملGenomics for natural product discovery
The Natural Product Discovery Institute contains a set of more than 30 000 fungal and actinomycete organisms that can be used for natural product discovery. The natural product library contains purified compounds, partially purified column fractions, and crude extracts from natural product-producing organisms. The collection is available for screening. This site describes a roadmap for analysin...
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ژورنال
عنوان ژورنال: Medicinal Research Reviews
سال: 2015
ISSN: 0198-6325
DOI: 10.1002/med.21380